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KMID : 1145520160020020084
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Journal of Radiopharmaceuticals and Molecular Probes
2016 Volume.2 No. 2 p.84 ~ p.95
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Application of extraction chromatographic techniques for separation and purification of emerging radiometals 44/47Sc and 64/67Cu
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Vyas Chirag K.
Park Jeong-Hoon
Yang Seung-Dae
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Abstract
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Considerably increasing interest in using the theranostic isotopes/ isotope pairs of radiometals like 44/47Sc and 64/67Cu for diagnosis and/or therapeutic applications in the nuclear medicine procedures necessitates its reliable production and supply. Separation and purification of no-carrier-added (NCA) isotopes from macro quantitates of the irradiated target matrix along with other impurities is a cardinal procedure amongst several other steps involved in its production. Multitudinous methods including but not limited to liquid-liquid (solvent) extraction, extraction chromatography (EXC), ion exchange, electrodeposition and sublimation are routinely applied either solitarily or in combination for the separation and purification of radioisotopes depending on their production routes, radioisotope of interest and impurities involved. However, application of EXC though has shown promises towards the numerous separation techniques have not received much attention as far as its application prospects in the field of nuclear medicine are concerned. Advances in the recent past for application of the EXC resins in separation and purification of the several medically important radioisotopes at ultra-high purity have shown promising behavior with respect to their operation simplicity, acidic and radiolytic stability, separation efficiencies and speedy procedures with the enhanced and excellent extraction abilities. In this mini review we will be talking about the recent developments in the application and the use of EXC techniques for the separation and purification of 44/47Sc and 64/67Cu for medical applications. Furthermore, we will also discuss the scientific and practical aspects of EXC in the view of separation of the NCA trace amount of radionuclides.
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KEYWORD
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Scandium - 44, 47(44/47Sc), Copper - 64, 67(64/67Cu), Theranostic isotope / isotope pair, Extraction chromatography (EXC), Radiochemical separation/ purification
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